Cholesterol Metabolism

Cholesterol builds and maintains cell membranes and defines some of its physical and biochemical properties. Lipoproteins transport cholesterol and triglyercides through a mammalian body . Cholesterol is essential for life , but a high level of cholesterol known as hypercholesterolemia, strongly associated with cardiovascular disease. Excess cholesterol was deposited in the arterial walls recruits macrophages , causing inflammation and fibrosis to form atherosclerotic plaques (atheromas ) , leading to atherosclerosis . Sources of cholesterol include novo biosynthesis and intestinal absorption . There are no identified mechanisms besides cholesterol catabolism or excretion of body oxysterols oxidation with different functions. The body carries cholesterol and recycled back with the aid of lipoproteins . Lipoprotein particles more commonly known 2 are low density lipoprotein (LDL ) and high density lipoprotein (HDL). LDL carries cholesterol from the liver to all other cells in the body. HDL picks up cholesterol from body tissues and brings it to the liver for storage. Complex signaling pathways leading processes move lipoprotein particles containing cholesterol from one organ to another and use or store cholesterol once you reach your destination . Taking into account their shared roles in controlling localization of cholesterol metabolism and signaling lipoprotein cholesterol are inexorably linked and often studied together.
CholesLo offers a wide range of technologies and signaling analysis of lipoprotein cholesterol metabolism research enables analysis of gene expression and regulation , epigenetic modification , genotyping and via activation of signal transduction . Metabolism studies optimized signaling and lipoprotein cholesterol matrix solutions include PCR , miRNA , siRNA, mutation analysis , via reporter , chromatin IP , DNA methylation and protein expression products .